Peer-reviewed veterinary case report
Retroperitoneal fibrosis after kidney transplant in cats
By Aronson, Lillian R·Published in Journal of the American Veterinary Medical Association·2002·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Retroperitoneal fibrosis in four cats following renal transplantation.
- Species:
- cat
Plain-English summary
Four cats developed serious complications after receiving kidney transplants, showing signs of kidney failure again 1 to 5 months later. They were diagnosed with retroperitoneal fibrosis, which is a buildup of scar tissue that can block the ureters and affect kidney function. To treat this, veterinarians performed surgery to remove the fibrous tissue causing the blockages. After the surgery, all four cats had their kidney function restored and did not experience any further obstructions.
People also search for: cat kidney transplant complications · cat ureter blockage treatment · retroperitoneal fibrosis in cats · cat azotemia after surgery
Abstract
Four cats developed fibrosis within the retroperitoneal space following renal transplantation. In human transplant patients, retroperitoneal fibrosis is an uncommon complication following surgery and may be secondary to operative trauma, infection, deposition of foreign material in the operative field, urinary extravasation, and perirenal hemorrhage caused by trauma to the allograft. Possible causes of fibrosis in the cats of this report include abdominal inflammation associated with allograft rejection, pyelonephritis, and septic peritoneal effusion. All of the cats of this report were readmitted to the veterinary teaching hospital following renal transplantation because of recurrence of azotemia 1 to 5 months after transplantation. Abdominal ultrasonography revealed a 2- to 4-mm-thick capsule surrounding the allograft in 2 of 4 cats, hydronephrosis in 4 cats, and hydroureter proximally in 2 cats. An exploratory laparotomy was performed in all cats to remove the fibrotic tissue causing the ureteral obstruction. Normal renal function was restored in all cats following surgery. Histologic evaluation of biopsy specimens revealed smooth muscle (3 cats) and fibrous connective tissue (4). All 4 cats, regardless of the cause, responded well to surgical resection of the scar tissue that was causing a ureteral obstruction. None of the cats had recurrence of obstruction following surgery.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12369701/