Peer-reviewed veterinary case report
Oxygen levels and survival in ventilated dogs with lung disease
By Stastny, Tereza et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2026·University of Pennsylvania School of Veterinary Medicine, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Retrospective Assessment of the Oxygenation Index in Dogs Undergoing Mechanical Ventilation for Primary Pulmonary Parenchymal Disease.
- Species:
- dog
Plain-English summary
A group of 79 dogs with serious lung problems were put on mechanical ventilation to help them breathe. Researchers found that dogs who survived had lower oxygenation index (OI) values and higher PaO/FiO (PF) ratios compared to those who did not survive. Specifically, a higher OI indicated a greater risk of death, with each unit increase raising the mortality risk by 35%. The study suggests that monitoring these values can help predict which dogs might recover better during treatment.
People also search for: dog breathing problems treatment · mechanical ventilation for dogs · dog lung disease survival rate
Abstract
OBJECTIVE: To assess the association between the oxygenation index (OI) and survival in mechanically ventilated dogs with primary pulmonary parenchymal disease. DESIGN: Retrospective, multicenter study. SETTING: Three veterinary medical teaching institutions and one private veterinary referral center. ANIMALS: Seventy-nine client-owned dogs. INTERVENTIONS: None. METHODS: OI, calculated as (mean airway pressure × FiO × 100) / PaO, and the PaO/FiO(PF) ratio were calculated for dogs undergoing mechanical ventilation for primary pulmonary disease. Median OI was lower in survivors (2.6) than nonsurvivors (6.6; p < 0.001), while PF was higher in survivors (317.9 vs. 177.9; p < 0.001). OI predicted mortality with an area under the receiver operating characteristic curve of 0.73, sensitivity of 65%, and specificity of 80% at an optimal cutoff of 4.3. Median PF had an area under the receiver operating characteristic curve of 0.72, sensitivity of 70%, and specificity of 73% at an optimal cutoff of 237.8. Each 1-unit increase in OI was associated with a 35% higher mortality risk (odds ratio: 1.35; 95% confidence interval: 1.14-1.61). Survivors showed greater improvement in OI during ventilation (p = 0.004). Using Pediatric Acute Lung Injury Consensus Conference and pediatric acute respiratory distress syndrome thresholds, survival likelihood declined with increasing severity, with no survivors in the severe category (OI >16). Similar trends were observed using updated Pediatric Acute Lung Injury Consensus Conference-2 criteria and acute respiratory distress syndrome severity classifications. CONCLUSIONS: Higher OI values and lower PF ratios were associated with mortality in this group of mechanically ventilated dogs, with both metrics demonstrating similar predictive accuracy. Results suggest species-specific OI and PF thresholds are needed.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41711316/