Peer-reviewed veterinary case report
Radiation side effects and outcomes in dogs with nasal tumors
By Fu, Dah-Renn et al.·Published in Frontiers in veterinary science·2023·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective comparison of side effects and outcomes of three-dimensional conformal vs. intensity-modulated radiation therapy in the palliative-intent treatment (4 Gy × 5 daily fractions) of canine intranasal tumors (2010-2017).
- Species:
- dog
Plain-English summary
A group of dogs with intranasal tumors received radiation therapy to help relieve their symptoms. Out of 36 dogs treated, 84% showed improvement within about 12 days after finishing their treatment. The two types of radiation therapy used—3D conformal and intensity-modulated—had similar outcomes, with most side effects being mild and affecting the skin or mouth. Overall, both treatments were effective in managing symptoms with minimal side effects, allowing dogs to feel better without significant complications.
People also search for: dog intranasal tumor treatment · radiation therapy side effects in dogs · palliative care for dog cancer
Abstract
OBJECTIVE: To compare the occurrence of radiation side effects and treatment outcomes in dogs with intranasal tumors treated with a total dose of 20 Gy delivered in 5 daily 4 Gy fractions using computer-based 3D conformal (3DCRT) or intensity-modulated (IMRT) radiation therapy plans. DESIGN: Retrospective case series. MATERIALS AND METHODS: Medical records for dogs with intranasal tumors treated with 4 Gy × 5 fractions between 2010 and 2017 were reviewed. Radiation side effects, time to local progression (TTLP), progression-free survival (PFS) and survival time (OS) were evaluated. RESULTS: Thirty-six dogs (24 carcinomas, 10 sarcomas and 2 others) met the inclusion criteria. Sixteen were treated with 3DCRT and 20 with IMRT. Clinical signs improvement or resolution were reported in 84% of dogs. The median time to clinical signs improvement was 12 days (1-88 days) after the end of treatment. Eight dogs treated with 3DCRT (8/16, 50%) and 5 with IMRT (5/20, 25%) were documented acute radiation side effects. Almost all were classified as grade 1 skin, oral or ocular acute side effects. Only one dog in 3DCRT group was demonstrated grade 2 skin acute effects. The median TTLP for dogs treated with 3DCRT or IMRT was 238 days and 179 days, respectively (= 0.967). The median PFS for 3DCRT or IMRT was 228 days and 175 days, respectively (= 0.940). The median OS for 3DCRT or IMRT was 295 days and 312 days, respectively (= 0.787). No significantly differences were observed in side effects, TTLP, PFS and OS between 3DCRT and IMRT groups. CONCLUSIONS: Palliative-intent conformal radiation therapy given in five daily 4 Gy fractions relieved clinical signs with minimal radiation side effects, with no statistical difference in occurrence between 3DCRT and IMRT dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36998642/