Peer-reviewed veterinary case report
Survival and outcomes in dogs with leptospirosis kidney treatment
By Ioannou, Antonia Da Fonseca et al.·Published in Journal of veterinary internal medicine·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of 22 dogs with leptospirosis treated with extracorporeal renal replacement therapies (2018-2021).
- Species:
- dog
Plain-English summary
A group of 22 dogs diagnosed with acute kidney injury due to leptospirosis was treated with a specialized procedure called renal replacement therapy (RRT). Out of these dogs, 16 (73%) survived to go home, and most of those continued to do well for at least 30 days after discharge. The study found that dogs with more body systems affected and higher bilirubin levels (a sign of liver issues) were less likely to survive. Overall, RRT showed promising results for helping dogs recover from this serious condition.
People also search for: dog leptospirosis treatment · acute kidney injury in dogs · renal replacement therapy for dogs
Abstract
BACKGROUND: Outcomes of dogs with acute kidney injury secondary to leptospirosis (AKI-L) treated using renal replacement therapies (RRT) are poorly characterized. HYPOTHESIS/OBJECTIVES: Describe survival to discharge, short (≤30 days) and long-term (≥6 months) outcomes of AKI-L dogs receiving RRT and determine if there is a significant difference in maximum blood urea nitrogen (maxBUN), maximum creatinine (maxCr), maximum bilirubin (maxBili) and the number of body systems affected between survivors and non-survivors. ANIMALS: Twenty-two client-owned dogs with AKI-L receiving RRT. METHODS: Retrospective medical record review of dogs with AKI-L that received RRT between 2018 and 2021. RESULTS: Sixteen of 22 (73%) dogs survived to discharge. Of the survivors, 13 (81%) were alive >30 days from discharge and 12 (75%) were alive at 6 months from discharge. Factors significantly higher in non-survivors included number of body systems affected (survivors: 1 (19%), 2 (50%), 3 (25%) and 4 (6%) vs non-survivors: 3 (33.3%), and 4 (66.7%); P = .01) and median maxBili (survivors: 1.9 mg/dL; range, 0.1-41.6 vs non-survivors: 21.0 mg/dL; range, 12.3-38.9; P = .02). There was no significant difference in median maxBUN (survivors: 153.0 mg/dL; range, 67-257 vs non-survivors: 185.5 mg/dL; range, 102-218; P = .44) and median maxCr (survivors: 9.8 mg/dL; range, 6.2-15.9 vs non-survivors: 9.8 mg/dL; range, 8.4-13.5; P = .69) between survivors and non-survivors. CONCLUSIONS AND CLINICAL IMPORTANCE: Regardless of azotemia severity, dogs with AKI-L receiving RRT have a good survival rate to discharge. The number of body systems affected and hyperbilirubinemia might be associated with worse outcomes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38334229/