Peer-reviewed veterinary case report
Can low plasma protein predict blood transfusion in dogs
By Buseman, Miranda et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2024·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of admission total plasma protein as a predictor of red blood cell transfusion requirement in dogs diagnosed with traumatic and nontraumatic hemoabdomen: 90 dogs (2009-2019).
- Species:
- dog
Plain-English summary
A group of 90 dogs diagnosed with hemoabdomen, a condition where blood accumulates in the abdomen, were evaluated to see how their total plasma protein levels affected the need for blood transfusions. The study found that for every 1 g/dL decrease in plasma protein, the chances of needing a transfusion doubled. Dogs with nontraumatic hemoabdomen were more likely to require transfusions compared to those with traumatic cases. Other factors like low red blood cell counts and high lactate levels also indicated a higher need for transfusions. Understanding these factors can help veterinarians make better decisions about treatment.
People also search for: dog hemoabdomen treatment · dog blood transfusion need · low plasma protein in dogs
Abstract
OBJECTIVE: To evaluate the association of admission total plasma protein (TPP) and the administration of red blood cell transfusions in dogs with diagnosed hemoabdomen. To secondarily evaluate additional point-of-care parameters associated with red blood cell transfusion administration. DESIGN: Retrospective study between 2009 and 2019. SETTING: University veterinary teaching hospital. ANIMALS: Ninety dogs admitted to a university veterinary teaching hospital after a diagnosis of traumatic or nontraumatic hemoabdomen (NTH). MEASUREMENTS AND MAIN RESULTS: Medical records were retrospectively reviewed; signalment, point-of-care diagnostics, and transfusion administration information was recorded. A total of 47 dogs (traumatic hemoabdomen 11/26; NTH 36/64) received packed red blood cell transfusions. For each 1 g/dL unit decrease in TPP, dogs had an increased odds ratio (OR) of 2.14 (95% confidence interval [CI]: 1.44-3.40, P < 0.001) of receiving a red blood cell transfusion. Dogs diagnosed with NTH were more likely to receive a red blood cell transfusion than dogs with a traumatic hemoabdomen (OR: 2.78, 95% CI: 1.11-7.141, P = 0.03). Lower PCV values (OR: 1.08, 95% CI: 1.04-1.12, P < 0.001), bicarbonate values (OR: 1.3, 95% CI: 1.09-1.56, P = 0.003), and base excess (OR: 1.27, 95% CI: 1.1-1.49, P = 0.003) were associated with a higher likelihood of red blood cell transfusion. Additionally, higher lactate (OR: 1.35, 95% CI: 1.16-1.63, P < 0.001) and Acute Patient Physiologic and Laboratory Evaluation (APPLE)scores (OR: 1.10, 95% CI: 1.04-1.17, P < 0.001) were associated with increased red blood cell transfusion administration. CONCLUSIONS: Low admission TPP, independent of low PCV, was associated with red blood cell transfusions regardless of underlying cause. For each 1 g/dL unit decrease in TPP on presentation, dogs were approximately 2 times more likely to receive a red blood cell transfusion during hospitalization. Other factors that were associated with increased transfusion administration included presenting PCV, PCV/TPP ratio, bicarbonate, base excess, lactate, and APPLEscores.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37961036/