Peer-reviewed veterinary case report
Red blood cell transfusion age and complications in dogs 2010-2012
By Maglaras, Christina H et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2017·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of the effect of red blood cell product age on occurrence of acute transfusion-related complications in dogs: 210 cases (2010-2012).
- Species:
- dog
Plain-English summary
A group of 210 dogs received blood transfusions, and researchers looked into whether the age of the blood products affected any complications. They found that older blood products were linked to a higher risk of hemolysis, which is when red blood cells break down too quickly. Fever was the most common complication, but the age of the blood did not increase the risk of death. The study suggests that using fresher blood products may help reduce the risk of certain complications during transfusions.
People also search for: dog blood transfusion complications · why is my dog having a fever after transfusion · hemolysis in dogs after blood transfusion
Abstract
OBJECTIVE: To determine whether red blood cell (RBC) product age influences the occurrence of acute transfusion-related complications and mortality in dogs. The hypothesis was that acute transfusion-related complications and mortality would increase with age of product. DESIGN: Retrospective study (2010-2012). SETTING: University teaching hospital. ANIMALS: Two hundred and ten clinical canine patients. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Medical records were reviewed for dogs receiving RBC-containing products. Patient signalment; reason for transfusion; product type, dose, age, and source; pretransfusion compatibility; rate, route, and method of administration; administration of multiple transfusions; underlying disease; occurrence of transfusion-related complications (eg, fever, hemolysis, gastrointestinal distress, cardiovascular, neurologic, and respiratory complications); various hematologic parameters; and survival were recorded. Data were analyzed for association between potential risk factors and occurrence of transfusion-related complications as well as between transfusion-related complications and survival. Of 333 transfusion events in 210 patients, 84 transfusion-related complications occurred. Fever was most common (41/333), followed by hemolysis (21/333). For every additional day of product age, the odds of hemolysis increased significantly (odds ratio, 1.11; 95% confidence interval, 1.06-1.16; P < 0.0001). Transfusion-related complications when considered as a whole were associated with higher dose of product, longer duration of administration per transfusion event, and immune-mediated disease, but not with source of product or general category of anemia. Administration rate was significantly slower in patients with febrile transfusion-related complications (P < 0.0001). Product age was not associated with increased mortality. CONCLUSIONS: Age of stored RBC products is associated with increased risk of transfusion-related hemolysis, but not with fever. Prospective clinical studies evaluating the influence of storage duration on development of in vitro versus in vivo hemolysis are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27669368/