Peer-reviewed veterinary case report
Phenoxybenzamine effects on heart and blood pressure in dogs
By Willette, Craig et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2024·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Retrospective evaluation of the influence of phenoxybenzamine pretreatment on intraoperative cardiovascular variables in dogs with pheochromocytoma.
- Species:
- dog
Plain-English summary
A group of dogs with a type of adrenal tumor called pheochromocytoma underwent surgery to remove the tumor, with some receiving a medication called phenoxybenzamine before the procedure. The study found that the dogs who were pretreated with phenoxybenzamine did not show any significant cardiovascular benefits during surgery compared to those who did not receive the medication. In fact, the pretreated dogs experienced more episodes of high blood pressure during the operation. This suggests that phenoxybenzamine may not be helpful for managing blood pressure in these cases, and more research is needed to understand its effects.
People also search for: dog pheochromocytoma surgery · high blood pressure in dogs · phenoxybenzamine for dogs
Abstract
OBJECTIVE: To compare cardiovascular outcomes in dogs undergoing adrenalectomy for pheochromocytoma with and without phenoxybenzamine pretreatment. ANIMALS: A total of 65 medical records from dogs at 5 veterinary hospitals. PROCEDURE: Records from January 2004 to December 2021 were evaluated for systolic, mean, and diastolic arterial pressures; numbers of hypertensive and hypotensive episodes; highest and lowest systolic arterial pressure differences; dose and duration of phenoxybenzamine; and presence of intraoperative arrhythmias. Phenoxybenzamine-pretreated dogs (Group PT,= 33) and dogs not receiving phenoxybenzamine (Group N,= 31) were compared. The Shapiro-Wilk test was used to test for normality, Student's-test was used for normally distributed data, and Fisher's exact test was used for ordinal and categorical data. Multivariable logistic regression was used to assess effect of pretreatment with phenoxybenzamine on occurrence of hypotension and hypertension, allowing for adjustment for confounding variables (< 0.05). RESULTS: Median (range) phenoxybenzamine dose was 0.46 (0.08 to 2.0) mg/kg, PO, q12h. Peak systolic and mean arterial pressures, lowest systolic and mean arterial pressures, duration of hypertension, duration of sinus tachycardia, number of hypotensive episodes, and duration of hypotension were not different between groups. More hypertensive episodes (= 0.01) and anesthetic events involving hypertension (= 0.02) were recorded in Group PT than in Group N. CONCLUSION: In dogs undergoing adrenalectomy for pheochromocytoma, phenoxybenzamine pretreatment as administered did not offer any cardiovascular benefits based on the measured variables, and may be associated with more intraoperative hypertensive episodes. CLINICAL RELEVANCE: Intraoperative changes in cardiovascular variables are prevalent in dogs with pheochromocytoma undergoing adrenalectomy. Further evaluation of pretreatment with phenoxybenzamine is needed to determine its role in these cases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39649740/