Peer-reviewed veterinary case report
Survival times and factors after surgery for dogs
By Smith, Ashley A et al.·Published in Journal of the American Veterinary Medical Association·2019·View original on PubMed →
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Original publication title: Retrospective study of survival time and prognostic factors for dogs with small intestinal adenocarcinoma treated by tumor excision with or without adjuvant chemotherapy.
- Species:
- dog
Plain-English summary
A group of 29 dogs diagnosed with small intestinal adenocarcinoma (a type of cancer) underwent surgery to remove the tumor, with some receiving additional chemotherapy. On average, these dogs lived about 544 days after surgery, with younger dogs (under 8 years) having a significantly longer survival time compared to older dogs. The study found that factors like lymph node metastasis and the use of chemotherapy or pain medications did not significantly affect how long the dogs lived after treatment. Overall, the prognosis for dogs with this type of cancer after surgery is considered fair, even if the cancer has spread to lymph nodes.
People also search for: dog small intestinal cancer treatment · dog adenocarcinoma survival rate · chemotherapy for dog cancer
Abstract
OBJECTIVE To estimate survival time for dogs with small intestinal adenocarcinoma (SIACA) following tumor excision with or without adjuvant chemotherapy and to identify factors associated with survival time. DESIGN Retrospective case series with a nested cohort study. ANIMALS 29 client-owned dogs with surgically resected, histologically diagnosed SIACA. PROCEDURES Medical records were reviewed and data collected regarding dog signalment; clinical signs; physical examination findings; PCV; serum total solids concentration; diagnostic imaging results; tumor size, location, and histologic characteristics (serosal extension, lymphatic invasion, surgical margins, and lymph node metastasis); type of adjuvant chemotherapy; NSAID administration; and survival time. Variables were assessed for associations with survival time and hazard rate via Kaplan-Meier and Cox proportional hazards analyses. RESULTS Overall median survival time for dogs with SIACA following tumor excision was 544 days (95% confidence interval, 369 to 719 days). Based on Kaplan-Meier estimates, the 1- and 2-year survival rates were 60% and 36%, respectively. On multivariate analysis, only age category was an independent predictor of survival over the follow-up period. Dogs < 8 years of age had a significantly longer median survival time (1,193 days) than dogs ≥ 8 years (488 days). Lymph node metastasis, adjuvant chemotherapy, NSAID administration, and other assessed variables were not associated with survival time. CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that SIACA in dogs carries a fair prognosis following excision, even when lymph node metastasis is present. Prospective studies are warranted to better characterize the effects of adjuvant chemotherapy or NSAID administration on survival time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30605388/