Peer-reviewed veterinary case report
Isoxazoline drugs for treating demodicosis in dogs and cats
By Zhou, Xueying et al.·Published in Journal of the American Veterinary Medical Association·2020·View original on PubMed →
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Original publication title: Review of extralabel use of isoxazolines for treatment of demodicosis in dogs and cats.
- Species:
- dog
Plain-English summary
A dog or cat diagnosed with demodicosis, a skin condition caused by mites, can be treated with isoxazolines, which have shown to reduce mite counts by over 99% in just one month. Unlike the FDA-approved treatment, amitraz, which can cause serious side effects like sedation and breathing problems, isoxazolines have fewer risks and are effective. This makes them a promising option for pet owners looking for safer treatments for their pets' skin issues. Many veterinarians are considering isoxazolines as a viable alternative for managing demodicosis.
People also search for: dog demodicosis treatment · cat skin mites medication · isoxazolines for dog skin problems
Abstract
Amitraz is presently the only FDA-approved treatment for demodicosis in dogs in the United States. Amitraz treatment involves a protracted course of administration and risks of severe adverse effects such as sedation, bradycardia, and respiratory depression, which are caused by activation of α-adrenergic receptors. Other treatment options include macrocyclic lactones and lime sulfur, but these products have varied efficacy and high risks of adverse effects. Several recent studies have indicated that isoxazolines are capable of reducingmite counts in canine and feline patients with demodicosis by ≥ 99% in as little as 1 month with few adverse effects. This article reviews the status of isoxazolines in regard to labeled uses in dogs and cats in the United States, extralabel clinical use for treatment of demodicosis in these species, and safety of orally administered formulations of these drugs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32459587/