Peer-reviewed veterinary case report
MDR1 gene mutation causes drug sensitivity in Collie dogs
By Fecht, S & Distl, O·Published in DTW. Deutsche tierarztliche Wochenschrift·2008·Institute of Animal Breeding and Genetics, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Review of prevalence, genetic aspects and adverse effects of the mdr1-1Delta mutation in dogs.
- Species:
- dog
Plain-English summary
A Collie with a genetic mutation called MDR1-1Delta can have severe reactions to certain medications, leading to symptoms like drooling, confusion, or even coma. This mutation affects how the dog's body processes drugs, making them more sensitive to toxic effects. If your dog is a breed known to carry this mutation, it's crucial to inform your veterinarian before any treatment, as they may need to choose alternative medications to avoid serious side effects. Understanding this genetic issue can help keep your dog safe and healthy.
People also search for: Collie drug sensitivity · MDR1 mutation in dogs · dog medication reactions · how to treat Collie with MDR1 mutation · signs of drug toxicity in dogs
Abstract
A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs which provoke adverse effects are structurally different. Although they are used for many different indications, all of these drugs are substrates of a transporting protein encoded by the MDR1 gene. This P-glycoprotein loses its normal protecting function at the tissue barriers in dogs with the mdrl-1Delta mutation. This article gives a short overview about the present state of analyses regarding the canine MDR1 gene. The genetic background, effects and prevalence in affected dog breeds of the mdrl-1Delta mutation are summarized. On the one hand, the overview might help practical veterinarians to understand the aetiology of drug sensitivity in dogs with the mdrl-1Delta mutation, and on the other hand, it might point out appendages for future research works about the canine MDR1 gene as well as for breeding strategies in affected dog breeds.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18605373/