Peer-reviewed veterinary case report
How can a new Mg-based mesh help with bone regeneration?
By Li S et al.·2026·School of Materials Science and Engineering, China·View original on Europe PMC →
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Original publication title: Revolutionizing Mg-based guided bone regeneration mesh derived from endogenous dentoalveolar bone augmentation.
- Species:
- dog
Plain-English summary
Researchers have been working on improving the way we help heal the bone in the jaw, which can be tricky because of its unique shape and function. They created a special mesh made from magnesium alloys that can break down safely in the body and help bone grow back. This mesh was tested in beagle dogs and was able to effectively repair bone defects without needing extra materials. It showed that it could maintain its structure for about a month before breaking down and helped create a lot of new bone over 12 weeks. Overall, this new mesh appears to be a promising option for helping with jawbone regeneration.
Abstract
Ideal regeneration of alveolar bone remains challenging due to its irregular morphology, complex structure, and unique biological functions. Advances in computer-aided design (CAD) and additive manufacturing (AM) have facilitated the development of customized bone grafts, making the repair of complex alveolar defects feasible. Magnesium (Mg) alloys with biodegradability, excellent osteogenesis and mechanical properties have been in high demand for guided bone regeneration (GBR) applications. However, the clinical application of Mg alloys is hindered by rapid degradation. Thus, this study developed a customized Mg-alloy GBR mesh via digital modeling and laser powder bed fusion (LPBF), with a strontium-doped octacalcium phosphate (SrOCP) coating to regulate degradation and osteogenesis. Sustained release of Mg<sup>2+</sup> and Sr<sup>2+</sup> activated the PI3K/Akt pathway, significantly promoting endogenous bone regeneration. In beagle models, the mesh achieved effective repair of alveolar defects (15 mm × 8 mm × 5 mm) without extra collagen membranes or bone substitutes. It showed controlled degradation (92.16% volume retention at 4 weeks, >80% degradation at 12 weeks) and strong osteogenic capability (new bone volume fraction 86.89% at 12 weeks). Collectively, a promising GBR strategy with biodegradable LPBF Mg-alloy mesh to facilitate the alveolar bone regeneration is proposed.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/42011202