Peer-reviewed veterinary case report
Dog develops muscle breakdown and dark urine after propofol anesthesia
By Cervone, Mario et al.·Published in Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)·2023·Dé, France·View original on PubMed →
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Original publication title: Rhabdomyolysis and myoglobinuria following single induction dose of propofol in a dog.
- Species:
- dog
Plain-English summary
A 5-year-old male Shih-Tzu developed dark urine a few hours after receiving anesthesia with propofol for dental work. The dog experienced muscle damage (rhabdomyolysis) and myoglobinuria, which is the presence of muscle protein in urine, along with some other blood abnormalities. After receiving IV fluids for about two days, the dog returned to normal and the dark urine cleared up.
People also search for: dog dark urine after anesthesia · Shih-Tzu muscle damage treatment · propofol side effects in dogs
Abstract
OBJECTIVE: To report a case of rhabdomyolysis and myoglobinuria following single induction dose of propofol in a dog. CASE SUMMARY: A 5-year-old intact male Shih-Tzu dog was presented for pigmenturia occurring a few hours following anesthesia for comprehensive oral health assessment and treatment. After premedication with IV diazepam (0.5 mg/kg), anesthesia was induced with IV propofol (4 mg/kg) and maintained with isoflurane vaporized in oxygen. A few hours following recovery from anesthesia, the dog developed rhabdomyolysis and myoglobinuria associated with increased serum alanine aminotransferase and C-reactive protein concentrations, as well as mild hypokalemia and euglycemic glycosuria. Approximately 48 hours after IV fluid therapy, the dog was clinically normal, and myoglobinuria progressively resolved. NEW OR UNIQUE INFORMATION PROVIDED: This is the first case description of rhabdomyolysis and myoglobinuria following a single dose of injectable propofol.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35870123/