Peer-reviewed veterinary case report
Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease.
- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Year:
- 2013
- Authors:
- Mealer, Robert G et al.
- Affiliation:
- Solomon H. Snyder Department of Neuroscience · United States
- Species:
- rodent
Abstract
Although the mutated protein causing Huntington's disease (HD) is expressed throughout the body, the major pathology of HD is localized to the striatum of the brain. We previously reported that the striatal-enriched protein Rhes binds the mutated huntingtin protein and enhances its cytotoxicity. We now demonstrate that Rhes-deleted mice are dramatically protected from neurotoxicity and motor dysfunction in a striatal-specific model of HD elicited by 3-nitropropionic acid. This finding suggests that Rhes may, in part, determine the striatal selectivity of HD.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23447628/