Peer-reviewed veterinary case report
Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2024
- Authors:
- Wasserman, Sean et al.
- Affiliation:
- Institute for Infection and Immunity · United Kingdom
- Species:
- rabbit
Abstract
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39028192/