Peer-reviewed veterinary case report
Risk factors for histiocytic sarcoma in Bernese mountain dogs
By Ruple, A & Morley, P S·Published in Journal of veterinary internal medicine·2016·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Risk Factors Associated with Development of Histiocytic Sarcoma in Bernese Mountain Dogs.
- Species:
- dog
Plain-English summary
Bernese Mountain Dogs (BMDs) are at a higher risk of developing a rare and aggressive cancer called histiocytic sarcoma (HS), especially if they have orthopedic problems. A study found that BMDs with joint issues were more likely to get HS, while those receiving prescription anti-inflammatory medications had a lower risk of developing this cancer. This suggests that managing inflammation in these dogs might help reduce the chances of getting HS. If you have a BMD, it’s important to discuss any joint problems and treatment options with your veterinarian.
People also search for: Bernese Mountain Dog cancer risk · histiocytic sarcoma in dogs · anti-inflammatory medication for dogs · dog joint problems and cancer risk
Abstract
BACKGROUND: Histiocytic sarcoma (HS) is a rare but aggressive malignancy in humans that is poorly responsive to existing treatments. Although rare in most breeds of dogs, HS is common in Bernese mountain dogs (BMDs). OBJECTIVE: Determine risk factors associated with development of HS in BMD. ANIMALS: A total of 216 BMD were registered with the Berner-Garde Foundation. METHODS: An internet-based cross-sectional survey was used to collect information from owners of BMD diagnosed with HS and owners of disease-free littermates of dogs with HS. Mixed-effects logistic regression (MELR) and conditional logistic regression (CLR) were used in parallel to examine associations between potential risk factors and the occurrence of HS. RESULTS: When controlling for litter as a marker of relatedness, dogs diagnosed with orthopedic conditions were found to be more likely to develop HS (MELR, OR: 2.5, 95% CI: 1.5, 5.2; CLR, OR: 2.81, 95% CI: 1.1, 7.3), whereas dogs receiving prescription anti-inflammatory medications were found to be at considerably lower risk of developing HS (MELR, OR: 0.42, 95% CI: 0.2, 0.8; CLR, OR: 0.32, 95% CI: 0.1, 0.8). CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest inflammation may be a modifiable risk factor for the development of HS in BMD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27160025/