Peer-reviewed veterinary case report
Survival factors in dogs with oral squamous cell carcinoma
By Fulton, Amy J et al.·Published in Journal of the American Veterinary Medical Association·2013·William R. Pritchard Veterinary Medical Teaching Hospital Small Animal Clinic, United States·View original on PubMed →
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Original publication title: Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990-2010).
- Species:
- dog
Plain-English summary
A group of 31 dogs with oral squamous cell carcinoma (a type of mouth cancer) was studied to see how treatment affected their chances of survival. Dogs that underwent surgery to remove the tumor had a much better outcome, with a 93.5% survival rate after one year, compared to no survivors among those who did not receive surgery. The study also found that the risk of death increased with certain tumor characteristics, such as inflammation around the tumor. Overall, surgical treatment significantly improved survival for these dogs, making it a crucial option for pet owners to consider.
People also search for: dog mouth cancer treatment · oral squamous cell carcinoma in dogs · dog cancer surgery survival rate
Abstract
OBJECTIVE: To identify risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma (OSCC) that were and were not treated with curative-intent surgery. DESIGN: Retrospective case series. ANIMALS: 31 dogs with OSCC. PROCEDURES: Medical records for dogs with OSCC that were not treated, or were treated with curative-intent surgery only between January 1990 and December 2010 were reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, and survival time were obtained from the medical record, and archived biopsy specimens were evaluated to identify the histologic subtype of the tumor and extent of tumor-associated inflammation (TAI), perineural invasion (PNI), and lymphovascular invasion (LVI). RESULTS: Risk of death for the 21 dogs with OSCC that were surgically treated was decreased 91.4% (hazard ratio, 0.086; 95% confidence interval, 0.002 to 0.150), compared with that for the 10 dogs with OSCC that were not treated. The 1-year survival rate was 93.5% and 0% for dogs that were and were not surgically treated, respectively. Risk of death increased significantly with increasing TAI and increasing risk score (combination of TAI, PNI, and LVI). Tumor location, clinical stage, and histologic subtype were not associated with survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that the prognosis for dogs with OSCC was excellent following surgical excision of the tumor. Risk of death increased with increasing TAI, and combining TAI, PNI, and LVI into a single risk score may be a useful prognostic indicator for dogs with OSCC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23971850/