Peer-reviewed veterinary case report
Risk factors for thyroid hormone changes in dogs with other diseases
By Nishii, Naohito et al.·Published in The Journal of veterinary medical science·2019·Joint Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Risk factors for low plasma thyroxine and high plasma thyroid-stimulating hormone concentrations in dogs with non-thyroidal diseases.
- Species:
- dog
Plain-English summary
A group of 207 dogs with various health issues was studied to understand how certain factors might affect their thyroid hormone levels. About half of these dogs had low levels of thyroxine (T4), while a significant number had high levels of thyroid-stimulating hormone (TSH). Factors like being an intact male, having severe health problems, and being a Labrador Retriever were linked to low T4 levels. Meanwhile, older dogs, spayed females, and Miniature Dachshunds were more likely to have high TSH levels. Understanding these risks can help veterinarians better manage thyroid issues in dogs with other health conditions.
People also search for: dog thyroid problems · low T4 in dogs · high TSH in dogs · Labrador thyroid issues · Miniature Dachshund health risks
Abstract
The aim of the current study was to identify independent risk factors for thyroid axis alterations in dogs with non-thyroidal diseases. In this retrospective cross-sectional study, data and plasma samples from 207 dogs with non-thyroidal diseases was used. The involvement of various factors (disease severity, sex, age, breed, category and duration of disease, and medication) in the alteration of plasma thyroxine (T4) or thyroid-stimulation hormone (TSH) concentrations was analyzed using multivariate logistic regression. Among the 207 dogs analyzed, 99 (47.8%) had low plasma T4 concentrations, while 45 (21.7%) had high TSH concentrations. Intact male sex [odds ratio (OR), 3.25; 1.67-6.35; P<0.001], Labrador Retrievers (OR, 18.70; 2.32-151.00; P=0.006), moderate (OR, 2.39; 1.21-4.74; P=0.012) and severe diseases (OR, 6.84; 2.27-20.70; P<0.001) were associated with increased risk for low plasma T4 concentrations. Meanwhile, intact male (OR, 3.93; 1.51-10.30; P=0.005), spayed female (OR, 4.22; 1.59-11.20; P=0.004), older age (OR, 2.73; 1.28-5.84; P=0.009), and Miniature Dachshunds (OR, 5.39; 2.38-12.20; P<0.001) had increased risk for high plasma TSH concentrations. Disease severity had been determined as an independent risk factor for canine NTIS. In addition, sex, age and breed were also associated with thyroid axis alterations in dogs with non-thyroidal diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31204368/