Peer-reviewed veterinary case report
Risk factors for side effects of piroxicam in dogs with cancer
By Eichstadt, L R et al.·Published in Veterinary and comparative oncology·2017·Veterinary Teaching Hospital, United States·View original on PubMed →
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Original publication title: Risk factors for treatment-related adverse events in cancer-bearing dogs receiving piroxicam.
- Species:
- dog
Plain-English summary
A group of dogs with cancer were treated with piroxicam, a medication that can help fight tumors but may cause side effects. Researchers found that older dogs and those taking stomach-protecting medications were more likely to experience gastrointestinal issues as a result of the treatment. Understanding these risk factors can help veterinarians weigh the benefits and potential problems when deciding whether to use piroxicam for their cancer patients.
People also search for: dog cancer treatment piroxicam side effects · older dog cancer medication risks · gastrointestinal issues in dogs on piroxicam
Abstract
Piroxicam has antitumour effects in dogs with cancer, although side effects may limit its use. The purpose of this study was to retrospectively identify factors predisposing cancer-bearing dogs to adverse events (AEs) following piroxicam therapy. Medical records of dogs presented to the Purdue Veterinary Teaching Hospital between 2005 and 2015 were reviewed, and 137 dogs met the criteria for study inclusion. Toxic effects of piroxicam in these dogs were graded according to an established system. Multivariate logistic regression was used to estimate the extent to which certain factors affected the risk for AEs. Age [odds ratio (OR) 1.250, P = 0.009; 95% confidence interval (CI) 1.057-1.479] and concurrent use of gastroprotectant medications (OR 2.612, P = 0.025; 95% CI 1.127-6.056) significantly increased the risk for gastrointestinal AEs. The results of this study may help inform the risk versus benefit calculation for clinicians considering the use of piroxicam to treat dogs with cancer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27714960/