Peer-reviewed veterinary case report
No link between dog genes and cruciate ligament rupture risk
By Clements, D N et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2011·Royal (Dick) School of Veterinary Studies, United Kingdom·View original on PubMed →
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Original publication title: Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex.
- Species:
- dog
Plain-English summary
A study looked at whether certain genetic factors were linked to cranial cruciate ligament (CCL) ruptures in Labrador Retrievers and Golden Retrievers. Researchers analyzed DNA samples from dogs with CCL injuries and compared them to healthy dogs of the same breeds. They found no specific genetic markers that could predict the risk of CCL rupture in either breed. This suggests that the cause of CCL injuries may not be related to genetic factors or autoimmune issues.
People also search for: dog CCL rupture risk · Labrador Retriever knee injury · Golden Retriever ligament problems
Abstract
OBJECTIVES: To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog. METHODS: DNA samples from populations of Labrador Retrievers and Golden Retrievers with CCL rupture and general populations of the same breeds were characterised for three DLA class II loci (DRB1*, DQA1* and DQB1*) alleles using sequence-based typing or reference strand-mediated conformation analysis. RESULTS: Although distinct differences in haplotype types, frequencies and homozygozity were observed between the two breeds, no disease specific association could be identified for the development of the CCL rupture within either population. CLINICAL SIGNIFICANCE: The risk for developing CCL rupture was not associated with DLA haplotype group(s) in Labrador Retrievers or Golden Retrievers, thus the hypothesis that there is an autoimmune basis to CCL rupture was not supported.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21597649/