Peer-reviewed veterinary case report
Risk of tuberculosis reactivation with tofacitinib (CP-690550).
- Journal:
- The Journal of infectious diseases
- Year:
- 2012
- Authors:
- Maiga, Mamoudou et al.
- Affiliation:
- Johns Hopkins School of Medicine · United States
Abstract
Individuals with latent tuberculosis infection (LTBI) live with a risk of reactivation, and several treatments for chronic inflammatory conditions are highly associated with such reactivation. A new Janus kinase inhibitor, tofacitinib (CP-690550), has shown promising results for treatment of inflammatory disorders, thus raising concerns of risk of active tuberculosis. Our goal was to characterize the impact of tofacitinib on LTBI using a mouse model of contained tuberculosis. Our data indicate that tofacitinib reduces host containment of Mycobacterium tuberculosis and promotes bacterial replication in the lungs, suggesting tuberculosis reactivation. Tofacitinib may carry a significant risk for LTBI reactivation in humans.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22474037/