Peer-reviewed veterinary case report
RNAIII-inhibiting-peptide-loaded polymethylmethacrylate prevents in vivo Staphylococcus aureus biofilm formation.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2007
- Authors:
- Anguita-Alonso, Paloma et al.
- Affiliation:
- Mayo Clinic College of Medicine · United States
- Species:
- rodent
Abstract
Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17116671/