Peer-reviewed veterinary case report
Robenacoxib helps reduce joint pain in cats with arthritis
By Adrian, Derek et al.·Published in Scientific reports·2021·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial.
- Species:
- cat
Plain-English summary
A group of cats with chronic joint pain were treated with a medication called robenacoxib to see if it could help improve their activity levels and overall well-being. After six weeks, the cats receiving robenacoxib showed a significant reduction in disability, and their owners reported improvements in their temperament and happiness. While the increase in activity was modest, more cats on robenacoxib experienced noticeable benefits compared to those on a placebo. Overall, robenacoxib proved to be effective for managing pain associated with joint disease in cats.
People also search for: cat joint pain treatment · robenacoxib for cats · improving cat happiness with joint pain
Abstract
The main objective of this pilot clinical trial was to evaluate outcome measures for the assessment of the nonsteroidal anti-inflammatory drug (NSAID) robenacoxib in cats with degenerative joint disease-associated pain (DJD-pain). Otherwise healthy cats (n = 109) with DJD-pain entered a parallel group, randomized, blinded clinical trial. Cats received placebo (P) or robenacoxib (R) for two consecutive 3-week periods. Treatment groups were PP, RR, and RP. Actimetry and owner-assessment data were collected. Data were analyzed using mixed-effects and generalized mixed-effects linear models. Activity data showed high within-cat and between-cat variability, and 82.4% of the values were zero. Compared to placebo, mean total activity was higher (5.7%) in robenacoxib-treated cats (p = 0.24); for the 80th percentile of activity, more robenacoxib-treated cats had a > 10% increase in activity after 3 (p = 0.046) and 6 weeks (p = 0.026). Robenacoxib treatment significantly decreased owner-assessed disability, (p = 0.01; 49% reduction in disability; effect size ~ 0.3), and improved temperament (p = 0.0039) and happiness (p = 0.021) after 6 weeks. More robenacoxib-treated cats were successes at 6 weeks (p = 0.018; NNT: 3.8). Adverse effect frequencies were similar across groups. Results identified suitable endpoints for confirmatory studies, while also indicating efficacy of robenacoxib in cats with DJD-pain.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33833276/