Peer-reviewed veterinary case report
Carboplatin and surgery helped dogs with tonsil cancer live longer
By Murphy, S et al.·Published in The Journal of small animal practice·2006·Animal Health Trust·View original on PubMed →
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Original publication title: Role of carboplatin in multi-modality treatment of canine tonsillar squamous cell carcinoma--a case series of five dogs.
- Species:
- dog
Plain-English summary
Five dogs with tonsil cancer were treated with a combination of surgery, radiation, and a chemotherapy drug called carboplatin. While tonsil cancer is aggressive and often has a poor outlook, two of the dogs lived significantly longer than average, surviving 826 and 1628 days after diagnosis without showing signs of disease. The treatment was generally well tolerated, with only one dog experiencing side effects from the carboplatin. This approach of combining surgery, radiation, and chemotherapy may offer a promising option for managing this type of cancer in dogs.
People also search for: dog tonsil cancer treatment · carboplatin for dogs · canine squamous cell carcinoma prognosis
Abstract
Canine tonsillar squamous cell carcinoma is an aggressive disease with a poor prognosis. A retrospective study was undertaken of all dogs that were presented between January 1999 and January 2004 to the Animal Health Trust for the treatment of tonsillar squamous cell carcinoma. Five cases were identified, and their median survival time was 211 days (95 per cent confidence interval 80 to 352) with two of the five dogs remaining alive at the end of the study, 826 and 1628 days from diagnosis with no clinical signs of disease. The protocol was well tolerated with only one of the five dogs showing toxicity associated with carboplatin and all dogs that started radiotherapy completing it. Compared with results of previous studies, these cases suggest that surgical cytoreduction followed by coarse fractionated radiotherapy together with carboplatin may be a useful way to treat this tumour. Carboplatin alone caused partial remission in the two cases where it was used as neo-adjunctive therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16573766/