Peer-reviewed veterinary case report
Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis.
- Journal:
- Journal of neuroimmunology
- Year:
- 2005
- Authors:
- Kato, Shingo et al.
- Affiliation:
- Second Department of Internal Medicine · Japan
- Species:
- rodent
Abstract
Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient mice against wild-type mice. Nociceptin expression increased in wild-type mice after DSS treatment. These results suggest stimulation by Noc/oFQ deteriorates colonic inflammation via up-regulation of adhesion molecule.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15748940/