Peer-reviewed veterinary case report
Serum HMGB1 levels predict outcomes in dogs with acute pancreatitis
By Lee, Jeong-Hwa et al.·Published in Research in veterinary science·2021·Department of Veterinary Clinical Science, South Korea·View original on PubMed →
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Original publication title: Role of serum high-motility group box-1 (HMGB1) concentration as a prognostic factor in canine acute pancreatitis: A pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with acute pancreatitis had their blood tested for a molecule called HMGB1, which can indicate the severity of their condition. The study found that dogs with higher levels of HMGB1 were more likely to have severe pancreatitis and a worse outcome. Specifically, dogs that did not survive had significantly higher HMGB1 levels compared to those that did. This suggests that measuring HMGB1 in the blood could help veterinarians predict how serious a dog's pancreatitis is and what the likely outcome might be.
People also search for: dog pancreatitis symptoms · high HMGB1 levels in dogs · pancreatitis treatment for dogs
Abstract
High-mobility group box-1 (HMGB1) is an intranuclear molecule that is released extracellularly in cytotoxic conditions. In acute pancreatitis, extracellular HMGB1 acts as a stimulating factor in the mechanism associated with pancreatic injury. To evaluate the prognostic property of serum HMGB1 levels at the time of diagnosis of pancreatitis, the blood samples collected over 10 months from canine patients in Seoul National University Veterinary Medical Teaching Hospital (n = 29). The HMGB1 levels were measured with ELISA kit and results were analyzed correlation with patient's death, hospitalization cost and period. HMGB1 levels in patients with acute pancreatitis (mean = 76 ng/mL, standard deviation [SD] = 46.99 ng/mL) were higher than that of normal individuals (mean = 31.65 ng/mL, SD = 18.41 ng/mL, p = 0.0082). Similarly, non-survivors demonstrated statistically significant difference than the survivors (p = 0.008). Clinical severity of acute pancreatitis was categorized into three stages: mild, moderate, and severe based on the disease activity index (DAI). The HMGB1 levels and mortality were associated with moderate DAI (p = 0.0236). However, the correlation between serum HMGB1 and patients' hospitalization period and cost were not found to be significant (R = 0.01991). The evaluation of serum HMGB1 level at the time of diagnosis was identified as a potential prognostic factor to estimate the prognosis of acute pancreatitis in canines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34649188/