Peer-reviewed veterinary case report
Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.
- Journal:
- Journal of neural transmission (Vienna, Austria : 1996)
- Year:
- 2009
- Authors:
- Kolasiewicz, Wacław et al.
- Affiliation:
- Department of Neuro-Psychopharmacology
- Species:
- rodent
Abstract
The present study shows that JNJ 16259685-a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19551466/