Peer-reviewed veterinary case report
Role of the transcription factor NFIC in odontoblast gene expression.
- Journal:
- Journal of the California Dental Association
- Year:
- 2009
- Authors:
- Kim, Mi Young et al.
- Affiliation:
- University of Southern California · United States
- Species:
- rodent
Abstract
The transcription factor NFI-C is essential for root development. Mice lacking NFI-C develop abnormal roots and lose their teeth, resembling radicular dentin dysplasia I in humans. The purpose of this study was to understand the role of NFI-C in dentinogenesis. The authors found statistically significant increases in the expression of several mRNAs in cells lacking NFI-C, suggesting that these molecules might interfere with odontoblast cell migration and differentiation, and consequently with root development.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20066876/