Peer-reviewed veterinary case report
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse.
- Journal:
- Muscle & nerve
- Year:
- 2010
- Authors:
- Dodd, Stephen L et al.
- Affiliation:
- Department of Applied Physiology and Kinesiology · United States
Abstract
We examined reactive oxygen species as upstream activators of nuclear factor kappaB; (NF-kappaB) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Catalase, an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappaB and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19813194/