Peer-reviewed veterinary case report
Rosa laevigata polysaccharides help treat ulcerative colitis
By Peng, Song et al.·Published in Chemistry & biodiversity·2024·Institute of Traditional Chinese Veterinary Medicine, China·View original on PubMed →
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Original publication title: Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium-Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota.
- Species:
- dog
Plain-English summary
A group of healthy adult beagles developed ulcerative colitis, showing symptoms like weight loss and diarrhea after being treated with sodium dextran sulfate. Researchers found that giving these dogs a supplement made from Rosa laevigata polysaccharides helped improve their condition. The dogs showed significant recovery, with reduced diarrhea and weight loss, as the supplement helped balance their gut bacteria by increasing good bacteria and decreasing harmful ones. This suggests that this natural supplement could be beneficial for dogs suffering from similar gut issues.
People also search for: beagle diarrhea treatment · dog ulcerative colitis diet · Rosa laevigata for dogs
Abstract
Rosa laevigata Michx. polysaccharides (RLP) have been demonstrated to possess antioxidant and anti-inflammatory properties. However, the mechanisms and efficacy of these polysaccharide components in preventing ulcerative colitis (UC) remain to be elucidated. The efficacy and mechanisms of RLP were investigated in a study that utilized healthy adult beagles to establish a UC model, considering the similarities in gut microbiota between humans and dogs. In the study, the beagle model induced by sodium dextran sulfate exhibited typical symptoms of ulcerative colitis, such as weight loss and diarrhea. All these symptoms and changes were significantly ameliorated through oral supplementation of RLP. Additionally, microbial community analysis based on the 16S rDNA gene revealed that RLP alleviated UC by increasing the abundance of beneficial bacteria and reducing the abundance of harmful bacteria. In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38567653/