Peer-reviewed veterinary case report
Purified dog antibody treatment safe for cats with tick paralysis
By Padula, A M·Published in Australian veterinary journal·2022·Padula Serums Pty Ltd, Australia·View original on PubMed →
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Original publication title: Safety and efficacy of a purified canine immunoglobulin G formulation for treatment of 76 cats clinically affected by the Australian paralysis tick (Ixodes holocyclus).
Plain-English summary
A group of 76 cats suffering from tick paralysis caused by the Australian paralysis tick were treated with a purified canine immunoglobulin G (IgG) formulation. This treatment was given through a slow intravenous infusion, and it was found to be very safe, with no serious adverse reactions reported. While two cats experienced mild facial swelling that responded well to antihistamines, 95% of the cats survived and were able to leave the hospital. This new treatment option shows promise for effectively managing tick paralysis in cats without the severe side effects seen with previous treatments.
People also search for: cat tick paralysis treatment · cat facial swelling after tick treatment · safe treatments for cat tick bites
Abstract
Acute adverse reactions in cats administered unrefined canine paralysis tick (Ixodes holocyclus) antiserum are commonly observed by veterinarians and can lead to significant morbidity and potentially fatal. A purified antiserum canine IgG concentrate was chromatographically prepared and aseptically formulated in single doses containing the equivalent of 5 mL of unrefined tick antiserum (TAS). The IgG was used for slow intravenous infusion into clinically affected cats at multiple veterinary clinics on the eastern seaboard of Australia. Overall, 72/76 (95%) of cats survived hospital discharge, an efficacy comparable to published data. A subset of 22 cats previously treated with unrefined TAS and considered high risk were included in the dataset. The safety profile was excellent with 0/76 acute adverse reactions although 2/76 (2.6%) developed mild facial swelling within 2 h of infusion that responded to the antihistamine. In conclusion, cats intravenously infused with purified IgG from canine TAS did not exhibit the expected frequency of acute adverse reactions during infusion and it was both safe and effective for the treatment of tick paralysis in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35788553/