Peer-reviewed veterinary case report
Stem cell treatment safety for early mitral valve disease in dogs
By Jeung, Soyoung et al.·Published in Frontiers in veterinary science·2024·VIP Animal Medical Center, South Korea·View original on PubMed →
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Original publication title: Safety and efficacy of canine gonadal tissue-derived mesenchymal stem cells for early myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of 16 dogs with early myxomatous mitral valve disease (MMVD), a common heart problem, received treatment with stem cells derived from gonadal tissue to see if it could help their condition. After a year, the dogs that received the stem cell treatment showed no significant worsening of their heart function, while those that did not receive the treatment experienced a decline. The treated dogs also had improved quality of life, including better appetite, and they were able to delay progression to a more severe stage of the disease without needing heart medication. This suggests that stem cell therapy could be a promising option for dogs with early MMVD.
People also search for: dog heart disease treatment · myxomatous mitral valve disease in dogs · stem cell therapy for dogs heart problems
Abstract
INTRODUCTION: This study explored the potential efficacy and safety of therapy with mesenchymal stem cells (MSC) derived from gonadal tissue to address the early stage of myxomatous mitral valve disease (MMVD), the predominant cardiac condition in dogs. METHODS: Sixteen dogs diagnosed with MMVD B1 were enrolled in this trial and assigned to either a control group (control group, = 10) or a group that received MSC derived from gonadal tissue (treatment group, = 6). In the treatment group, allogeneic MSC derived from gonadal tissue (1 × 10cells/kg) were intravenously administered at monthly intervals for five or more sessions. Data were compared at baseline and at the endpoint 1-year intervals. The efficacy was assessed using echocardiography, thoracic radiography, NT-proBNP, and the duration from B1 diagnosis to B2 transition to evaluate its effect on MMVD stage progression. Safety was evaluated through physical examinations, blood tests, imaging studies, and monitoring of adverse events. RESULTS: After 1 year of observation, the control group exhibited deteriorating echocardiographic parameters, whereas the treatment group displayed no substantial differences between baseline and endpoint measurements. Notably, a statistically significant disparity was noted in the left atrial diameter ( < 0.05) and E-wave velocity ( < 0.05) between the two groups, indicating a favorable impact of MSC derived from the gonadal tissue on left atrial pressure. Additionally, in contrast to the control group, the treatment group demonstrated delayed progression to MMVD stage B2, enabling them to prolong their disease duration without requiring cardiac medication ( = 0.038). In quality of life (QoL) metrics following MSC treatment, appetite showed a statistically significant improvement, increasing from 4 to 4.83 ( < 0.05). DISCUSSION: Treatment with gonadal tissue-derived MSCs significantly delayed MMVD stage progression, highlighting the broad potential of MSC derived from gonadal tissue for treating complex veterinary conditions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39415950/