Peer-reviewed veterinary case report
Tranexamic acid IV safely causes vomiting in dogs after swallowing
By Orito, Kensuke et al.·Published in The Journal of veterinary medical science·2017·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Safety and efficacy of intravenous administration for tranexamic acid-induced emesis in dogs with accidental ingestion of foreign substances.
- Species:
- dog
Plain-English summary
A group of 137 dogs that accidentally ingested foreign substances were treated with tranexamic acid, a medication that helps induce vomiting. This treatment successfully made 94% of the dogs vomit, with most dogs starting to vomit within two minutes. While a few dogs experienced mild side effects, like a seizure or bleeding issues, they both recovered with medical care. In cases where one dose wasn't enough, a second or third dose also helped induce vomiting effectively.
People also search for: dog vomiting after eating something foreign · tranexamic acid for dogs · what to do if my dog ate something toxic
Abstract
A prospective observational study was performed in canine clinical medicine to evaluate the emetic action and adverse effects of tranexamic acid. Veterinarians treated 137 dogs with a single dose of tranexamic acid (50 mg/kg, IV) after accidental ingestion of foreign substances. If needed, a second (median, 50 mg/kg; range, 20-50 mg/kg, IV) or third dose (median, 50 mg/kg; range, 25-50 mg/kg, IV) was administered. Tranexamic acid induced emesis in 116 of 137 (84.7%) dogs. Median time to onset of emesis was 116.5 sec (range, 26-370 sec), median duration of emesis was 151.5 sec (range, 30-780 sec), and median number of emesis episodes was 2 (range, 1-8). Second and third administrations of tranexamic acid induced emesis in 64.7 and 66.7% of dogs, respectively. In total, IV administration of tranexamic acid successfully induced emesis in 129 of 137 (94.2%) dogs. Adverse effects included a tonic-clonic convulsion and hemostatic disorder in two different dogs, both of which recovered after receiving medical care. Tranexamic acid induced emesis in most dogs following a single-dose. When a single dose was not sufficient, an additional dosage effectively induced emesis. Overall, adverse effects were considered low and self-limiting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29093310/