Peer-reviewed veterinary case report
Safety of alternate-day TS-1 cancer treatment in dogs
By Nishiyama, Yuta et al.·Published in The Journal of veterinary medical science·2021·Veterinary Teaching Hospital, Japan·View original on PubMed →
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Original publication title: Safety of alternate-day treatment with TS-1(tegafur/gimeracil/oteracil) in tumor-bearing dogs: a pilot study.
- Species:
- dog
Plain-English summary
Eleven dogs with tumors were treated with a combination medication called TS-1, which is taken by mouth on alternate days. While some dogs showed no improvement or had worsening conditions, two dogs had a partial response or stable disease. There were some side effects, but they were manageable. Overall, TS-1 may be a helpful option for treating certain types of cancer in dogs.
People also search for: dog cancer treatment options · TS-1 for dogs · side effects of cancer medication in dogs
Abstract
Tegafur is a prodrug of fluoropyrimidine 5-fluorouracil (5-FU), while TS-1is an oral fixed-dose combination of three active drugs, tegafur, gimeracil, and oteracil. This pilot study evaluated the safety of tegafur/gimeracil/oteracil in the treatment of cancers in dogs. Tegafur/gimeracil/oteracil was administered orally at a mean dose of 1.1 mg/kg twice daily on alternate days, Monday-Wednesday-Friday, every week to 11 dogs with tumors. Partial response and stable disease were observed in one dog each, whereas six exhibited progressive disease. Three dogs were not assessed. Adverse events, the most serious being grade 2, were noted in seven dogs. Adverse events were acceptable, and the drug was effective in some dogs. Therefore, tegafur/gimeracil/oteracil may be useful for treating malignant solid tumors in canines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34148911/