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Peer-reviewed veterinary case report

Safety of giving Bravecto and worm medicine together in dogs

By Walther, Feli M et al.·Published in Parasites & vectors·2014·MSD Animal Health Innovation GmbH, Germany·View original on PubMed

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Original publication title: Safety of concurrent treatment of dogs with fluralaner (Bravecto™) and milbemycin oxime-praziquantel.

Species:
dog

Plain-English summary

A study looked at the safety of giving dogs fluralaner (Bravecto) for flea and tick control along with milbemycin oxime and praziquantel, which are used to treat heartworm and intestinal worms. Some minor and temporary side effects were noticed, but none were linked to the combination of these medications. Overall, the dogs tolerated the concurrent treatment well without serious issues. This means that pet owners can feel confident using these treatments together for their dogs.

People also search for: dog flea and tick treatment · Bravecto safety · heartworm prevention for dogs · milbemycin oxime side effects

Abstract

BACKGROUND: Fluralaner (Bravecto™; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routinely used to control Dirofilaria immitis and intestinal worm infections in dogs. The safety of concurrent use of fluralaner and a commercially available milbemycin oxime plus praziquantel combination tablet, in particular with regard to gastrointestinal symptoms, was investigated using oral doses at or above the maximum recommended rates. FINDINGS: Some minor and transient clinical findings were observed during the study period; however, none of these was considered to be related to concurrent treatment with fluralaner and milbemycin oxime plus praziquantel, or to the use of either product alone. CONCLUSIONS: Concurrent treatment with fluralaner, milbemycin oxime and praziquantel is well tolerated in dogs.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25315498/