Peer-reviewed veterinary case report
Safety of masitinib treatment in healthy cats tested
By Daly, M et al.·Published in Journal of veterinary internal medicine·2011·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Safety of masitinib mesylate in healthy cats.
- Species:
- cat
Plain-English summary
Twenty healthy cats were given a medication called masitinib mesylate to see if they could tolerate it without serious side effects. Most of the cats handled the treatment well, but a few experienced issues like protein in their urine and low white blood cell counts. Some cats also had increased kidney values and stomach problems. While masitinib may be safe for many cats, more research is needed to understand its long-term effects.
People also search for: cat medication side effects · masitinib for cats · healthy cat kidney problems
Abstract
BACKGROUND: Masitinib mesylate is a PO-administered tyrosine kinase inhibitor developed both for human and animal diseases with activity against both mutated and wild type forms of the c-kit receptor and platelet-derived growth factor receptors α and β, and is currently registered in Europe for the treatment of mast cell tumors in dogs. HYPOTHESIS/OBJECTIVES: The objective of this study was to determine if healthy cats can tolerate administration of masitinib without clinically relevant adverse effects. ANIMALS: Twenty healthy research colony-specific pathogen-free cats. METHODS: This study was a prospective, randomized phase 1 clinical trial. Masitinib was administered PO to 20 healthy cats. Ten cats received 50 mg masitinib every other day for 4 weeks, and 10 cats received 50 mg masitinib daily for 4 weeks. RESULTS: Clinically relevant proteinuria was noted in 2/20 (10%) cats (both treated daily), and neutropenia was noted in 3/20 (15%) (seen in both treatment groups). An increase in serum creatinine concentration and adverse gastrointestinal effects were noted in some cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Masitinib mesylate was tolerated in the majority of cats. Long-term administration and pharmacokinetic studies are needed to further assess the use of masitinib in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21314730/