Peer-reviewed veterinary case report
Safety of low-dose ketoprofen for long-term use in healthy dogs
By Narita, Tatsuya et al.·Published in American journal of veterinary research·2006·Department of Clinical Veterinary Science, Japan·View original on PubMed →
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Original publication title: Safety of reduced-dosage ketoprofen for long-term oral administration in healthy dogs.
- Species:
- dog
Plain-English summary
A group of 14 healthy Beagles was given a lower dose of ketoprofen, a common pain medication, for 30 days to see if it was safe for long-term use. While the dogs did not show any serious kidney or bleeding problems, some developed mild to moderate stomach issues, particularly in the area near the stomach outlet. Tests showed increased signs of potential stomach bleeding in the dogs taking ketoprofen compared to those not receiving the medication. Pet owners should be aware that while ketoprofen can help with pain, it may cause some gastrointestinal side effects.
People also search for: dog pain medication side effects · Beagle stomach problems · ketoprofen for dogs safety
Abstract
OBJECTIVE: To evaluate the safety of reduced-dosage ketoprofen (RDKET) for long-term oral administration in healthy dogs. ANIMALS: 14 healthy Beagles. PROCEDURES: Racemic ketoprofen (0.25 mg/kg, PO) and gelatin capsules, as a drug-free placebo, were each administered to 7 dogs for 30 days. Dogs were periodically monitored via physical examination, blood analyses, endoscopic examinations, fecal occult blood tests (tetramethylbenzidine and guaiac methods), renal function tests (effective renal plasma flow and glomerular filtration rate), urinalyses, urinary enzyme indices (N-acetyl-beta-D-glucosaminidase and gamma-glutamyl-transferase), and hemostatic function tests (buccal mucosa bleeding time, cuticle bleeding time, prothrombin time, activated partial thromboplastin time, and fibrinogen concentration). RESULTS: Pyloric antrum lesion grade was significantly higher in the RDKET group on day 28, compared with the pretreatment and control group grades. Fecal occult blood grade measured by use of the tetramethylbenzidine method was significantly higher in the RDKET group on day 30, compared with the pretreatment grade. No other significant differences were detected between treatment groups. CONCLUSIONS AND CLINICAL RELEVANCE: RDKET induced mild to moderate gastric mucosal injuries especially in the pyloric antrum in healthy Beagles, whereas no adverse effects were observed in renal function or hemostasis. Fecal occult blood tests may be useful as screening tests for adverse gastrointestinal effects induced by RDKET in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16817730/