Peer-reviewed veterinary case report
Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma.
- Journal:
- Cancer letters
- Year:
- 2013
- Authors:
- Berger, Elisa et al.
- Affiliation:
- Department of Experimental Obstetrics and Gynecology · Germany
Abstract
Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23337288/