Peer-reviewed veterinary case report
Saponins from Polygala japonica and their effects on a forced swimming test in mice.
- Journal:
- Journal of natural products
- Year:
- 2006
- Authors:
- Li, Ting-Zhao et al.
- Affiliation:
- Department of Phytochemistry · China
- Species:
- rodent
Abstract
Five new triterpenoid saponins, polygalasaponins E (1), F (2), G (3), H (4), and J (5), along with eight known ones (6-13), were isolated from the aerial parts of Polygala japonica. Their structures were established by chemical and spectroscopic means. Forced swimming tests on mice showed that saponins 1 and 4 significantly reduce the immobility status by 58.1% and 51.3% at a dosage of 100 mg/kg administrated orally once daily for 5 days, respectively.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16643032/