Peer-reviewed veterinary case report
SARS-CoV-2 Omicron EG.5 and JN.1 induce enhanced pathogenicity in K18-hACE2 mice compared with the early Omicron subvariants.
- Journal:
- Lab animal
- Year:
- 2026
- Authors:
- Ho, Mandy Tsoi Man et al.
- Affiliation:
- School of Public Health · China
- Species:
- rodent
Abstract
The reduced pathogenicity of early SARS-CoV-2 Omicron subvariants in human ACE2-expressing K18-hACE2 mice has posed challenges for assessing vaccine and antiviral efficacy against the Omicron variant with the mouse model. Here we report the enhanced pathogenicity of the Omicron JN.1 and EG.5 lineages in K18-hACE2 mice compared with their ancestors, suggesting the potential of applying these Omicron lineages in the mouse infection model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/41857361/