Peer-reviewed veterinary case report
SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats ().
- Journal:
- Viruses
- Year:
- 2018
- Authors:
- van Doremalen, Neeltje et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
Abstract
Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated frombats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infectbats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection inbats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30572566/