Peer-reviewed veterinary case report
Scaling skin and hair loss in three adult dogs from sebaceous gland
By Peters-Kennedy, Jeanine et al.·Published in Veterinary dermatology·2014·Department of Biomedical Sciences, United States·View original on PubMed →
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Original publication title: Scaling dermatosis in three dogs associated with abnormal sebaceous gland differentiation.
- Species:
- dog
Plain-English summary
Three adult dogs were brought in with severe skin problems, including scaling, hair casts, and poor coat quality that started when they were puppies. After taking skin samples for testing, the veterinarians treated them with topical agents, oral essential fatty acids, and vitamin A. Two of the dogs showed significant improvement in their skin condition and coat quality after treatment. While this condition, known as sebaceous gland dysplasia, is rare and cannot be cured, ongoing treatment can help manage the symptoms effectively.
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Abstract
BACKGROUND: Abnormal sebaceous gland differentiation, so-called 'sebaceous gland dysplasia', is a rare condition described in the dog and the cat. Although little is known about this condition, it is thought that a genetic defect causes abnormal sebaceous gland development. Clinically, this condition occurs in young cats and dogs and is characterized by variable degrees of adherent scale, hair casts, poor coat quality and hypotrichosis. HYPOTHESIS/OBJECTIVE: Here, we describe the clinical presentation and treatment of three adult dogs with abnormal sebaceous gland differentiation. ANIMALS: Three adult dogs presented with a keratinization defect characterized by progressive scaling, hair casts, dull, dry, brittle hair coat and hypotrichosis beginning in puppyhood to early adulthood. METHODS: Multiple 6 mm punch skin biopsy samples were obtained from each dog. Treatments included various topical keratomodulatory agents, oral essential fatty acids and oral vitamin A. RESULTS: Histologically, all sebaceous glands were small and composed of a mixture of irregularly clustered basal reserve cells and mature sebocytes. With therapy, two of the dogs showed moderate to marked clinical improvement in scaling, hair casts and hair coat quality. CONCLUSIONS AND CLINICAL IMPORTANCE: Although rare, 'sebaceous gland dysplasia' should be considered in cases where a primary keratinization defect is suspected. Given that abnormal sebaceous differentiation is a structural defect of the skin, treatment must be maintained and is aimed at ameliorating the clinical signs rather than curing the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24341629/