Peer-reviewed veterinary case report
No link found between 17 genes and cataracts in wire-haired Dachshunds
By Müller, Christina & Distl, Ottmar·Published in Veterinary journal (London, England : 1997)·2009·Institute for Animal Breeding and Genetics, Germany·View original on PubMed →
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Original publication title: Scanning 17 candidate genes for association with primary cataracts in the wire-haired Dachshund.
- Species:
- dog
Plain-English summary
A group of wire-haired Dachshunds with primary cataracts (a type of eye problem) was studied to see if certain genes were linked to this condition. Researchers looked at 17 different genes but found no significant connection between these genes and cataracts in the affected dogs. This suggests that the genes tested are not likely responsible for causing cataracts in this breed. Pet owners should be aware that cataracts can occur in Dachshunds, but these specific genes are not the cause.
People also search for: wire-haired Dachshund cataracts · dog eye problems · Dachshund gene study · primary cataracts in dogs
Abstract
Primary cataracts are breed-related eye diseases and are common in many dog breeds. In this study, 17 genes (BFSP2, EYA1, FOXE3, FTL, GCNT2, GJA3, GJA8, HSF4, MAF, MIP, PAX6, PITX3, SIX5, SORD, SOX1, SPARC, TRNT1) were evaluated as candidates for primary non-congenital cataracts (CAT) in the Dachshund using microsatellites adjacent to the candidate genes. Linkage and association with CAT was tested in 15 affected and six unaffected wire-haired Dachshunds. Non-parametric linkage analysis and association tests did not reveal significant linkage or association for the candidate gene flanking microsatellites tested. Thus, it is unlikely that the 17 investigated candidate genes harbour a causative mutation for CAT in these Dachshunds.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18703362/