Peer-reviewed veterinary case report
How inhaled fluticasone medicine spreads in healthy dogs' lungs
By Chow, K E et al.·Published in Journal of veterinary internal medicine·2017·Faculty of Veterinary and Agricultural Sciences, Australia·View original on PubMed →
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Original publication title: Scintigraphic Assessment of Deposition of Radiolabeled Fluticasone Delivered from a Nebulizer and Metered Dose Inhaler in 10 Healthy Dogs.
- Species:
- dog
Plain-English summary
Ten healthy Foxhounds were studied to see how well they could inhale a medication called fluticasone, which is used for treating breathing problems. The dogs were given the medication using either a nebulizer or a metered dose inhaler (MDI). The results showed that the nebulizer was more effective, allowing about 4.2% of the medication to reach the lungs compared to only 2.3% with the MDI. This study helps understand how different inhalation methods can affect medication delivery in dogs, which could be important for treating respiratory issues in pets.
People also search for: dog breathing problems treatment · fluticasone for dogs · nebulizer vs inhaler for dogs
Abstract
BACKGROUND: Aerosolized medications are increasingly being used to treat respiratory diseases in dogs. No previous studies assessing respiratory tract deposition of radiolabeled aerosols have been performed in conscious dogs. HYPOTHESIS/OBJECTIVES: Assess respiratory tract deposition of radiolabeled, inhalant corticosteroid (fluticasone propionate labeled withTc) delivered from a nebulizer and metered dose inhaler (MDI) to healthy dogs. ANIMALS: Ten healthy Foxhounds. METHODS: Prospective, randomized, cross-over pilot study. Initial inhalation method (nebulizer or MDI) was randomly assigned. Treatments were crossed over after a 7-day washout period. Treatments initially were performed using sedation. Dogs were imaged using 2-dimensional planar scintigraphy, with respiratory tract deposition quantified by manual region-of-interest analysis. Deposition calculated as percentage of delivered dose. Six of 10 dogs were randomly selected and reassessed without sedation. RESULTS: Inhalation method had significant effect on respiratory tract deposition (P = 0.027). Higher deposition was achieved by nebulization with mean deposition of 4.2% (standard deviation [SD], 1.4%; range, 1.9-6.1%); whereas MDI treatment achieved a mean of 2.3% (SD, 1.4%; range, 0.2-4.2%). Nebulization achieved higher respiratory tract deposition than MDI in 7 of 10 dogs. No statistical difference (P = 0.68) was found between mean respiratory tract deposition achieved in dogs when unsedated (3.8%; SD, 1.5%) or sedated (3.6%; SD, 1.7%). CONCLUSIONS AND CLINICAL IMPORTANCE: Study confirms respiratory tract deposition of inhalant medications delivered from a nebulizer and MDI in healthy dogs, breathing tidally with and without sedation. Respiratory tract deposition in these dogs was low compared to reported deposition in adult humans, but similar to reported deposition in children.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28961322/