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Mesenchymal stem cell treatments for cats and their effectiveness

By Webb, Tracy L & Webb, Craig B·Published in Journal of the American Veterinary Medical Association·2024·View original on PubMed

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Original publication title: Scoping review of the use of mesenchymal stem and stromal cell products in cats, Part 2: current scope and efficacy.

Species:
cat

Plain-English summary

A review of studies found that mesenchymal stem cells (MSCs) are being used to treat various diseases in cats, with chronic kidney disease being the most common condition treated. Out of 192 cats treated with MSC products, most did not experience any negative side effects. The results varied widely, with some cats showing no improvement while others achieved long-term recovery. These findings suggest that MSC treatments could be a promising option for cats with certain health issues, but more research is needed to confirm their effectiveness and safety.

People also search for: cat kidney disease treatment · mesenchymal stem cells for cats · chronic kidney disease in cats · cat stem cell therapy effectiveness

Abstract

A scoping review of published literature found 108 articles related to mesenchymal stem or stromal cell (MSC) use in cats. Twenty-four of the publications summarized the treatment of 192 cats with MSC products for 12 naturally occurring and induced diseases. These trials used a variety of cell sources, administration routes, delivery vehicles, and dosages. The majority of studies did not have a control group. The disease with the largest number of cats administered MSCs thus far is chronic kidney disease (n = 59 cats). The majority of cats had no adverse events associated with treatment, which supports continued interest in the potential use of MSC products to address unmet medical needs. Treatment outcomes of the 192 cats have ranged from no response to long-term cure, depending on the disease being treated and the particular study. Some of these early studies show promise and provide significant information to direct both the design and focus of larger clinical trials investigating the safety and efficacy of MSC treatment for veterinary and human applications.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38565137/