Peer-reviewed veterinary case report
Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry.
- Year:
- 2025
- Authors:
- Fechner A et al.
- Affiliation:
- Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. · Germany
Abstract
A novel coupling of a miniaturized thermal desorption chip (TDC) with a flexible microtube plasma (FµTP) ionization source and ion mobility spectrometry (IMS) enables direct, solvent-free analysis of a liquid sample. The integrated TDC-FµTP-IMS system combines sample introduction, preconcentration, and time-resolved desorption via adjustable temperature gradients. Quantitative analysis of a ketone mixture demonstrated excellent linearity and detection limits between 34 µg L<sup>-1</sup> and 79 µg L<sup>-1</sup>. In addition, N-hexanoyl homoserine lactone was successfully quantified from a liquid sample without manual preparation. The method provides a fast, sensitive, and selective approach for direct liquid-phase IMS applications.
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Search related cases →Original publication: https://europepmc.org/article/MED/40721959