Peer-reviewed veterinary case report
See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis.
- Journal:
- Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
- Year:
- 2015
- Authors:
- Kerever, Aurelien et al.
- Affiliation:
- Research Institute for Diseases of Old Age
- Species:
- rodent
Abstract
Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25833270/