Peer-reviewed veterinary case report
Seeing is believing: dynamic changes in renal epithelial autophagy during injury and repair.
- Journal:
- Autophagy
- Year:
- 2014
- Authors:
- Lin, Fangming et al.
- Affiliation:
- Department of Pediatrics
- Species:
- rodent
Abstract
Ischemic injury to the kidneys is a prevalent clinical problem, contributing importantly to chronic kidney disease. Yet, underlying molecular mechanisms are elusive. To address the possible role of autophagy, we engineered a novel strain of mice harboring a ubiquitously expressed CAG-RFP-EGFP-LC3 transgene. Using this tool, we examined the post-ischemic kidney and detailed the dynamics of renal tubular epithelial autophagy. In addition, we defined the role of MTOR in the resolution of autophagy during epithelial survival and kidney repair.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24434795/