Peer-reviewed veterinary case report
Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Palmer, Guy H et al.
- Affiliation:
- Department of Veterinary Microbiology and Pathology · United States
Abstract
Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17178787/