Peer-reviewed veterinary case report
Selective iNOS inhibitor L-NIL does not reduce cell death in ruptured
By Hofer, D et al.·Published in Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2009·Vetsuisse Faculty Berne·View original on PubMed →
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Original publication title: Selective iNOS-inhibition does not influence apoptosis in ruptured canine cranial cruciate ligaments.
- Species:
- dog
Plain-English summary
A group of dogs with torn knee ligaments (cranial cruciate ligaments) was studied to see if a specific treatment could reduce cell death in the damaged tissue. The treatment involved giving the dogs an oral medication that blocks nitric oxide production, which is thought to contribute to cell death. However, the results showed that this treatment did not significantly affect the amount of cell death in the ruptured ligaments. This suggests that other factors, not just nitric oxide, may be responsible for the cell death in these cases.
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Abstract
Abnormal patterns of cell death, including increased apoptosis, can influence homeostasis of ligaments and could be involved in the pathogenesis of cranial cruciate ligament (CCL) rupture. Increased nitric oxide (NO) production has been implicated as a stimulus to increased apoptosis in articular cartilage. This study investigated apoptotic cell death in ruptured canine CCL (CCL group, n = 15), in ruptured CCL of dogs treated with oral L-N6-(1-iminoethyl)-lysine (L-NIL), a selective NO-synthetase(NOS)-inhibitor, (L-NIL group, n = 15) and compared the results with normal canine CCL (control group, n = 10). Orally administered L-NIL at a dosage of 25mg/m2 of body surface area was effective in inhibiting NO production in the articular cartilage of dogs in the L-NIL group, but it did not significantly influence the increased quantity of apoptotic cells found in ruptured CCL specimens. The results of this study suggest that apoptosis of ligamentocytes in the canine CCL is not primarily influenced by increased NO production within the stifle joint.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19448875/