Peer-reviewed veterinary case report
New magnetoelastic stents can detect artery narrowing
By Chen G et al.·2026·Department of Bioengineering, United States·View original on Europe PMC →
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Original publication title: Self-powered in-stent restenosis diagnosis via magnetoelastic stents.
- Species:
- pig
Plain-English summary
Researchers have developed a new type of stent, called a smart magnetoelastic stent, which not only supports narrowed arteries but also monitors blood flow to detect problems like in-stent restenosis (when arteries narrow again after stent placement). This smart stent was tested in pigs, where it successfully sensed changes in blood flow using advanced technology. The studies showed that the stent is safe for use in living organisms. This innovative approach could change how we manage artery blockages and improve treatment for conditions like atherosclerosis. Overall, the treatment shows promise for better monitoring and management of artery health.
Abstract
Widely used in millions of atherosclerosis treatments, conventional metal stents, although pervasive, only provide mechanical support to narrowed arteries. However, many patients experience in-stent restenosis after implantation. Here we developed smart magnetoelastic stents that preserve mechanical functionality while enabling self-powered hemodynamic monitoring for continuous and timely diagnosis of in-stent restenosis. Using a clinical catheter, the smart stent is deployed in the swine carotid artery for in vivo hemodynamic sensing, enabling effective detection of induced stenosis through artificial intelligence-assisted signal interpretation. In vivo and in vitro studies demonstrate the biosafety of the smart stent through immune profiling, human cytokine analysis and single-cell RNA sequencing. These results underscore the smart stent's potential for seamless integration into biological systems as a reliable diagnostic tool. This platform technology could potentially revolutionize current stent technology and contribute to improved strategies for managing atherosclerosis.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41699202